Job Description

Overview Senior Scientist, Medicinal Chemistry at Altos Labs. We are seeking a talented and passionate Medicinal Chemist to join our small-molecule drug discovery team. In this role, you will contribute to advancing science and developing life-changing medicines. You will contribute to all stages of drug discovery, from hit identification to lead optimization, within a collaborative and fast-paced environment. Responsibilities Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection. Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology. Design and Synthesize Novel Compounds: Apply innovative structure- and computationally-driven, as well as property-based design principles, to design and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners. Analyze and Interpret Data: Utilize strong analytical thinking skills to organize and analyze structure-activity relationship (SAR) data sets to drive design ideas and impact program direction. Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity). Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry department support. Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders. Potential for Leadership: Demonstrate leadership potential towards leading chemistry programs, including managing external CRO chemistry FTEs. Qualifications Education and Experience: You possess a Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant experience in chemical research, preferably within a biotechnology or pharmaceutical setting. Expertise in Synthetic/Medicinal Chemistry: You have proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of at least one first-authored publication(s) and an understanding of medicinal chemistry principles. Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization. Structure-Based Drug Design: Experience with structure-based drug design is highly preferred. Strong Communicator: You convey strong verbal and written communication skills and a demonstrated ability to deliver effective presentations. Problem-Solver: You exhibit contemporary expertise and understanding of all aspects of synthetic organic chemistry, including modern synthetic methodologies, multi-step synthetic route design, compound purification, and characterization. Collaborative Team Player: You are highly collaborative, team-oriented, and considerate of the needs of the team. Results-Oriented: You are fearless in your pursuit of groundbreaking innovations and passionate about creating revolutionary medicines to address unmet patient needs. Salary Location: Redwood City, CA Senior Scientist I, Medicinal Chemistry: $195,000 - $264,000 Senior Scientist II, Medicinal Chemistry: $220,000 - $313,200 Exact compensation may vary based on skills, experience, and location. Privacy and Employment Notices For UK applicants, before submitting your application: Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice). This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. Equal Opportunity Employment Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief). Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at #J-18808-Ljbffr Altos Labs

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